Carisoprodol (trade names embody Soma, Somadril, Carisoma, Carisoprodol Watson, Listaflex, Somacid, Vanadom) is a muscle relaxant from carbamic acid esters pharmacological group. This treatment is indicated together with relaxation and physical therapy to alleviate musculoskeletal ache, skeletal muscle spasms, stiffness, muscle injuries, pressure, sprain, acute back pain, discomfort related to short-term, painful musculoskeletal conditions, and for different medical purposes. It can additionally be widely off-label used as leisure drug. Carisoprodol could additionally be prescribed alone for monotherapy or in combinations with different medication, similar to psycholeptics.
Clinical presentation </h2
Overdosage of Carisoprodol (Soma) tablets generally produces CNS despair. Death, coma, respiratory depression, hypotension, seizures, delirium, hallucinations, dystonic reactions, nystagmus, blurred imaginative and prescient, mydriasis, euphoria, muscular incoordination, rigidity, and/or headache have been reported with Soma overdosage. Serotonin syndrome has been reported with carisoprodol intoxication. Many of the carisoprodol overdoses have occurred within the setting of multiple drug overdoses (including drugs of abuse, illegal medication, and alcohol). The effects of an overdose of this treatment and different CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) may be additive even when one of many medicine has been taken in the really helpful dosage. Fatal unintended and non-accidental overdoses of SOMA have been reported alone or together with CNS depressants.
Treatment of overdosage
Basic life support measures must be instituted as dictated by the clinical presentation of the Soma overdose. Vomiting shouldn’t be induced due to the danger of CNS and respiratory melancholy, and subsequent aspiration. Circulatory help ought to be administered with volume infusion and vasopressor agents if wanted. Seizures should be handled with intravenous benzodiazepines and the reoccurrence of seizures may be treated with phenobarbital. In instances of severe CNS depression, airway protecting reflexes could additionally be compromised and tracheal intubation ought to be thought of for airway protection and respiratory help.
For decontamination in cases of severe toxicity, activated charcoal ought to be thought of in a hospital setting in sufferers with massive overdoses who current early and are not demonstrating CNS depression and might shield their airway.